Some variables can influence the efficiency of leukocyte removal filter for red cell concentrates. We performed this study to evaluate whether the filtration efficiency for platelet concentrates (PCs) can be influenced by bedside filter (PXL8K,
Pall
Corporation, USA) used, platelet storage time and transient stopping of platelet agitation, and to measure the amount of cytokines released from donor leukocytes in PCs during the storage time. In addition, we examined the effect of leukocyte
reduction
by filtration before the storage of PCs on the subsequent generation of cytokines. Any of the above mentioned variables did not make significant differences. From day 1 to day 5, there were significant increases in IL-1β(<1 vs, 8.6 pg/mL, p<
0.05),
IL-8(>10 vs. 455.3 pg/mL, p<0.05) and TNF-α (<4 vs. 16.6 pg/mL, p<0.05) in unfiltered PCs, whereas no increased levels of cytokines were found in the cases of prestorage filtration.
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